Hal's blizzard anhedonia (p. 853)
It occurred to me that without some one-hitters to be able to look forward to smoking alone in the tunnel I was waking up every day feeling as though there was nothing in the day to anticipate or lend anything any meaning. […] The implied question, then, would be whether the Bob Hope had somehow become not just the high-point of the day but its actual meaning. That would be pretty appalling. The Penn 4 that was my hand-strengthening ball for November was on the sill against the window. I’d neither carried nor squeezed my ball for several days. No one seemed to have noticed.
Context
The withdrawal ledger, tallied while Mario un-snores across the room: no Substance, therefore nothing "to anticipate or lend anything any meaning" — Ennet House's first lesson arrived at alone, without a program. The unsqueezed Penn 4 is the behavioral readout, and "No one seemed to have noticed" quietly widens the diagnosis to everyone around him.